Speaker Profile

Executive Summary：
Dr. Chiang graduated from Taipei Medical University and received her neurology residency training at Chang Gung Memorial Hospital, Linkou branch. She became an attending neurologist in the Neurology Department of Taipei Tzu Chi General Hospital and later changed gears to Taipei Veterans General Hospital in 2018. She was trained as a movement disorders clinical fellow in the Movement Disorder Unit of Westmead Hospital, Australia, with Prof. Victor Fung from 2014 to 2015. After returning from Sydney, she pursued her master’s degree at National Taiwan University with Prof. Chin-Hsien Lin. She's currently a member of the MDS-AOS education committee.

Lecture Abstract：
Parkinson's disease (PD) is typically recognized for its motor symptoms, but non-motor manifestations are common in PD and significantly impact patients' quality of life. Treatment options for non-motor symptoms in PD are often limited and not without side effects. This lecture delves into the management strategies for key non-motor symptoms (NMS) in PD, including cognitive impairment, psychiatric symptoms, autonomic dysfunction, and sleep disturbances. I will discuss pharmacological and non-pharmacological interventions tailored to address the specific needs of PD patients.

Executive Summary：
Marie Vidailhet is Professor of Neurology, in Salpêtrière Hospital, Sorbonne Université, Paris, France. She has a long-standing interest in movement disorders, Parkinson’s disease and dystonia and her main interest is movement disorders, both in clinic (National Reference center for Dystonia and ERN network) and research from pathophysiology to experimental therapeutics, within her research group (Mov’it) at the ICM research institute and contributed to the field of pathophysiology of dystonia and other rare movement disorders, and to development of therapeutic approaches (deep brain stimulation in dystonia), non-invasive stimulation in tremor.

She has always been actively involved movement disorders at the national and international level. She is actively involved in the Movement Disorders Society (past member of MDS International Executive Committee, of the Bylaw committee, Program Committee (and organisation of the 2009 international MDS conference in Paris past Secretary MDS-ES (European section), Faculty at the International MDS conferences and at the Winter and Summer MDS-ES courses,
She was appointed to the MDS Mentorship program and was awarded the Presidential lecture (Stanley Fahn Lecture) at the Hong-Kong international conference and the Brown Sequard Lecture (Presidential lecture) at the 2024 EAN conference. She is also involved at the European Level (Fellow of the European Neurogical Society Member of the EAN board, 2 terms). She is Member of Dystonia Coalition.

She is very invested in the mentorship and training of young neurologists and her group is happy to host since many years, fellows from all over Europe and beyond.
Over the years, she co-authored over 400 publications (total H index 91) with focus on the pathophysiology of dystonia, tremors and Tourette syndrome, deep brain stimulation in dystonia, development of non-invasive stimulation for dystonia and tremor, both for research and experimental therapeutics. Together with Stephane Lehericy (co-leader of the research team), she worked on clinical and neuroimaging characterization of Parkinson’s disease.

Lecture Abstract：
Since the MDS consensus for diagnosis and different types of tremors including the criteria for essential tremor, and other types of tremors including orthostatic tremor, a very active debate has developed on the definition and limits of essential tremor “plus” and on the differential diagnosis between dystonia with tremor jerky or tremulous tremor and, to date, there are still some debates both on phenomenology and on therapeutic approaches. Invasive and non-invasive stimulation were used either for therapeutics (DBS) or pathophysiology (TMS, TDCS) or both (FUS). There is also debate on the therapeutic target in the cerebello-thalamo-cortical pathways or Thalamic ventral-Oralis complex/rostral zona incerta. Dual stimulations are exploratory and part of research programs. Orthostatic tremor (14-18Hz) is a rare and disabling disorder with a 13-18 Hz tremor frequency in the standing position. Until now, several therapeutics attempts had little effect on patient’s disability. Spinal cord stimulation and deep brain stimulation provided some transient effect and more insight into the pathophysiology and exploratory approaches are still needed.

Executive Summary：
Jui-Cheng Chen, MD, PhD, is the director of the neurology department, China Medical University Hsinchu Hospital, and trustee of Taiwan Neurophysiology Society. Dr. Chen directs a multidisciplinary research program focused on the neurological diseases, such as dystonia and Parkinson disease by non-invasive recording and stimulation. Dr. Chen is interested in how these regulatory mechanisms contribute to both neurophysiological and pathological motility, and in leveraging this information for the development of therapeutics that target neurodegenerative diseases. Work of Dr. Chen has been supported by several grants from Ministry of Science Technology, Taiwan, Ministry of Education, Taiwan and DAAD, Germany. Dr. Chen earned his bachelor’s degree in Medicine from China Medical University and his Ph.D. in Neurology of University College London. After completing postdoctoral visiting at Oxford University in clinical neuroscience, he joined China Medical University.

Lecture Abstract：
In the study, MR-guided focused ultrasound (MRgFUS) thalamotomy effectively treated essential tremor (ET) by ablating the thalamic nucleus. This non-invasive technique offers precise lesioning with MRI guidance. Researchers explored using a tri-axis accelerometer to objectively assess treatment outcomes compared to subjective clinical rating scales (CRST). Ten ET patients underwent MRgFUS, with improvements recorded in both CRST and accelerometer-measured tremor severity. Quality of life also significantly improved post-treatment. The accelerometer correlated well with CRST scores. Conclusion: Accelerometers are objective tools for monitoring MRgFUS outcomes in ET, reducing examiner-related variability seen with clinical scales. This suggests potential for broader clinical use, offering reliable and consistent tremor assessment.